Zum Inhalt springenZur Suche springen


Veröffentlichungen aus jüngerer Zeit

AG Wagner

Originalarbeiten seit 2000

  • Schröder, O.  and Wagner, R.:  The bacterial DNA binding protein H-NS represses ribosomalRNA transcription by trapping RNA polymerase in the initiation complex. J. Mol. Biol. 298: 737-748 (2000).  undefinedPubmed
  • Schröder, O. , Tippner, D. and Wagner, R.: Towards the three-dimensional structure of the DNA-binding protein H-NS: a CD- and fluorescence study. Biochem. Biophys. Res. Commun. 282: 219-227 (2001). undefinedPubmed
  • Schäferkordt, J. and Wagner, R.: Effects of point mutations within an E. coli ribosomal RNA leader region on rRNA maturation and ribosome formation. Nucleic Acids Res. 29: 3394-3403 (2001). [Pubmed]
  • Wagner, R.: Regulation of ribosomal RNA synthesis in E. coli: effects of the global regulator guanosine tetraphosphate (ppGpp). J. Mol. Microbiol. Biotechnol. 4: 331-340 (2002). [Pubmed]
  • Dame R. , Wyman, C. Wurm, R., Wagner, R. and Goosen, N.: Structural basis for H-NS mediated trapping of RNA polymerase in the open initiation complex at the rrnB P1. J. Biol. Chem. 277: 2146-2150 (2002). [Pubmed]
  • Schröder, O. and Wagner, R.: The bacterial regulatory protein H-NS - a versatile modulator of nucleic acid structures. Biol. Chem. 383: 945-960 (2002). [Pubmed]
  • Reusch, R., Shabalin, O., Crumbaugh, A., Wagner, R., Schröder, O. and Wurm, R.: Posttranslational modification of E. coli histone-like protein H-NS and bovine histones by short-chain poly-(R)-3-hydroxybutyrate (cPHB). FEBS Lett. 527: 319-322 (2002). [Pubmed]
  • Jöres, L. and Wagner, R.: Essential steps in the ppGpp-dependent regulation of rRNA promoters can be explained by substrate competition. J. Biol. Chem. 278: 16834-16843 (2003). [Pubmed]
  • Hillebrand, A., Wurm, R., Menzel, A. and Wagner, R.: The seven E. coli ribosomal RNA operon upstream regulatory regions differ in structure and transcription factor binding efficiencies. Biol. Chem. 386:523-534 (2005). [Pubmed]
  • Dame, R. T., Luijsterburg, M. S., Krin, E., Bertin, P. N., Wagner, R.and Wuite, G. J.: DNA Bridging: a Property Shared among H-NS-Like Proteins. J. Bacteriol. 187: 1845-1848 (2005). [Pubmed]
  • Pul, Ü., Wurm, R., Lux, B., Meltzer, M., Menzel, A. and Wagner, R.: LRP and H-NS - cooperative partners for transcription regulation at Escherichia coli rRNA promoters. Mol. Microbiol. 58: 864-876 (2005). [Pubmed]
  • Pul, Ü., Wurm, R. and Wagner, R.: The Role of LRP and H-NS in Transcription regulation: involvement of synergism, allostery and macromolecular crowding. J. Mol. Biol. 366: 900-915 (2006). [Pubmed]
  • Gildehaus, N., Neußer, T., Wurm, R. and Wagner, R.: Studies on the function of the riboregulator 6S RNA from E. coli: RNA polymerase binding, inhibition of in vitro transcription and synthesis of RNA-directed de novo transcripts. Nucleic Acids Res. 35: 1885-1896 (2007). [Pubmed] [Faculty1000Biology]
  • Pul, Ü, and Wagner, R.: Nukleoid-assoziierte Proteine bei Mikroorganismen. Biospektrum 5: 495-497 (2007). [BIOspektrum]
  • Tiffert, Y., Supra, P., Wurm, R., Wohlleben, W., Wagner, R. and Reuther, J.: The Streptomyces coelicolor GlnR regulon: identification of new GlnR targets and evidence for a central role of GlnR in nitrogen metabolism in actinomycetes. Mol. Microbiol. 67: 861-880 (2008). [Pubmed]
  • Neußer, T. , Gildehaus, N., Wurm, R. and Wagner, R.: Studies on the expression of 6S RNA from E. coli: involvement of regulators important for stress and growth adaptation. Biol. Chem. 389: 285-297 (2008). [Pubmed]
  • Pul, Ü., Lux, B., Wurm, R. and Wagner, R.: Effect of upstream curvature and transcription factors H-NS and LRP on the efficiency of E. coli rRNA promoters P1 and P2 - A phasing analysis. Microbiology 154: 2533-2545 (2008). [Pubmed] [SGM-HotoffthePress]
  • Wagner, R.: Translational components in prokaryotes: genetics and regulation of ribosomes. Encyclopedia of Life Sciences, Nature Publishing Group, Macmillan Publishers Ltd., London. (2009). [ELS]
  • Giuliodori, A. M., Di Pietro, F., Marzi, S., Masquida, B., Wagner, R., Romby, P.. Gualerzi, C. O. and Pon, C. L.: The cspA mRNA is a thermosensor that modulates translation of the cold-shock protein CspA. Mol.Cell. 37: 21-33 (2010).[Pubmed] [Faculty1000Biology]
  • Neußer, T., Polen, T., Geißen, R. and Wagner, R.: Depletion of the non-coding regulatory 6S RNA in E. coli causes a surprising reduction in the expression of the translation machinery. BMC Genomics 11:165-178 (2010). [BMC Genomics]
  • Pul, Ü., Wurm, R., Arslan, Z., Geißen, R., Hofmann, N. and Wagner, R.: Identification and Characterization of E. coli CRISPR-cas Promoters and their Silencing by H-NS. (2010), Mol. Microbiol. 75:1495-1512 (2010). [Pubmed]
  • Wurm, R., Neußer, T. and Wagner, R.: 6S RNA-dependent inhibition of RNA polymerase is released by RNA-dependent synthesis of small de novo products. Biol. Chem. 39:187-196 (2010). [Pubmed]
  • Geißen, R., Steuten, B., Polen, T. and Wagner, R.: E. coli 6S RNA - a universal transcriptional regulator within the centre of growth adaptation. RNA Biol. 7: 564-568 (2010).
  • Westra, E. R., Pul, Ü., Heidrich, N., Jore, M. M., Lundgren, M., Stratmann, T., Wurm, R., Raine, A., Mescher, M., van Heereveld, L., Mastop, M., Wagner, E. G. H., Schnetz, K., van der Oost, J., Wagner, R. and Brouns, S. J. J.: H-NS mediated repression of CRISPR-based immunity in Escherichia coli K12 can be relieved by the transcription activator LeuO. Mol. Microbiol. 77: 1380–1393 (2010). [Pubmed] [Highlighted in MicroCommentary by F.J. Mojica and C. Díez-Villaseñor]
  • Jore, M. M., Lundgren, M., van Duin, E., Bultema, J. B., Westra, E. R., Waghmare, S. P., Wiedenheft, B., Pul, Ü., Wurm, R., Wagner, R., Beijer, M., Barendregt, R. A., Zhou, K., Snijders, A. P. L., Dickman, M. J., Doudna, J. A., Boekema, E. J., Heck, A. J. R., van der Oost, J. and Brouns, S. J. J.: Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nature Structural & Molecular Biology, 18: 529-536 (2011).
  • Hofmann, N., Wurm, R. and Wagner, R.: The E. coli Anti-Sigma Factor Rsd: Studies on the Specificity and Regulation of its Expression. PLoS ONE 6(5): e19235. doi:10.1371/journal.pone.0019235 (2011).
  • Wagner, R. and Pul, Ü: Abwehr gegen Fremd-DNA durch das bakterielle CRISPR/Cas-System. Biospektrum 4: 393-395 (2011). [BIOspektrum]
  • Kolmsee, T., Delic, D., Agyenim, T., Calles, C. and Wagner, R.: Differential stringent control of E. coli rRNA promoters: effects of ppGpp, DksA and the initiating nucleotides. Microbiology, 157: 2871-2879 (2011).
  • Rediger, A., Geißen, R., Steuten, B., Heilmann, B., Wagner, R. and Axmann, I. M.: 6S RNA – an old issue became blue-green. Microbiology, 158: 2480-2491 (2012).
  • Stratmann, T., Pul, Ü., Wurm, R., Wagner, R. and Schnetz, K.: RcsB-BglJ activates leuO, encoding an H-NS antagonist and pleiotropic regulator of virulence determinants. Mol. Microbiol. 83: 1109-1123 (2012).
  • Steuten, B. and Wagner, R.: A conformational switch is responsible for the reversal of the 6S RNA-dependent RNA polymerase inhibition in Escherichia coli Biol. Chem. 393: 1513–1522 (2012).
  • Ellinger, P., Arslan, Z., Wurm, R., Tschapek, B., MacKenzie, C., Pfeffer, K. Panjikar, S., Wagner, R., Schmitt, L., Gohlke, H., Pul, Ü. and Smits, S. H. J.: The crystal structure of the CRISPR-associated protein Csn2 from Streptococcus agalactiae. J. Structural Biol. 178: 350-362 (2012).
  • Arslan, Z., Stratmann, T., Wurm, R., Wagner, R., Schnetz, K. and Pul, Ü.: RcsB-BglJ-mediated activation of Cascade operon does not induce the maturation of CRISPR RNAs in E. coli K12. RNA Biol. 10: 708-715 (2013).
  • Arslan, Z., Wurm, R., Brener, O., Ellinger, P., Nagel-Steger, L., Oesterheld, F., Schmitt, L., Willbold, D., Wagner, R., Gohlke, H., Smith, S. H. J. and Pul, Ü.: Double-strand DNA end-binding and sliding of the toroidal CRISPR-associated protein Csn2. Nucleic Acids Res. 41: 6347-6359 (2013).
  • Steuten, B., Setney, P. Zacharias, M. and Wagner, R.: Mapping the Spatial Neighborhood of the Regulatory 6S RNA Bound to Escherichia coli RNA Polymerase Holoenzyme. J. Mol. Biol. 425: 3649-3661 (2013).
  • Marchfelder A, Maier L-K, Heidrich N, Pul Ü: Das Immunsystem der Prokaryoten: CRISPR-Cas. BiuZ 43(3), 158-165 (2013).
  • Steuten, B., Schneider, S. and Wagner, R.: 6S RNA: recent answers - future questions. Mol. Microbiol. 91(4): 641-648 (2014).
  • Steuten, B., Hoch, P., Damm, K., Schneider, S., Köhler, K., Wagner, R. and Hartmann, R. K.: Regulation of transcription by 6S RNAs - insights from the Escherichia coli and Bacillus subtilis model systems. RNA Biology 11(5).(2014).
  • Arslan, Z., Hermanns, V., Wurm, R., Wagner, R. and Pul, Ü.: Detction and characterization of spacer integration intermediates in type I-E CRISPR-Cas system. Nucleic Acids Res. 42 (12): 7884-7893 (2014).

Lehrbücher und Buchbeiträge

  • Wagner, R.: Transcription Regulation in Prokaryotes. Oxford University Press, 2000.
  • Wagner, R.: Protein-Nucleinsäure Wechselwirkungen. in Bioanalytik, Lottspeich, F. and Engels, J. W.,Spektrum-Akademischer Verlag, 2012
  • Wagner, R.: ppGpp Signaling. in Bacterial Signaling Kraemer, R. and Jung, K. (Eds.), 2010, Wiley VCH, Weinheim, ISBN: 978-3-527-32365.
  • Pul, Ü and Wagner, R.: Nucleoid-associated proteins - structural properties. In Bacterial Chromatin, Dame, R. T. and Dorman, C. J. (Eds.), 2009, Springer,  ISBN: 978-90-481-3472-4.
  • Wagner R. and Pul Ü.: CRISPR - a bacterial immunity system based on small RNAs. In: From Nucleic Acids Sequences to Molecular Medicine , V.A. Erdmann and J. Barciszewski, (Eds.), 2012  Springer, ISBN: 978-3-642-27426-8.
  • Arslan, Z., Westra, E. R., Wagner, R. and Pul, Ü.: Regulation of CRISPR-Based Immune Responses. in CRISPR-Cas Systems, R. Barrangou and J. and van der Oost (Eds.), Springer-Verlag,(2012) ISBN-13: 978-3642346569.